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Clinical studies: DermaZinc™ & DermaZinc™ Plus

Clinical studies: Proteque®

Clinical studies: Vasoderm™

Proteque®
Proteque®
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Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University
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Ciba Laboratories
University of California — San Francisco

Preventing irritant contact dermatitis:
an in vivo human study

Study Director: Howard Maibach, M.D.
Principal Investigator: Hongbo Zhai, M.D.
Technical Assistance: Alessandra Pelosi, M.D.




Prepared by:
Hongbo Zhai, M.D.
Department of Dermatology
University of California
San Francisco, CA 94143



Study Objective
This study was to evaluate the efficacy of a Proteque formulation against sodium lauryl sulfate (SLS) induced irritation by visual grading and bioengineering techniques in humans.

1) Visual scoring (VS) of erythema showed a decrease on the Proteque pretreated testing site in comparison to SLS only treated site; and it also significantly decreased the VS on Proteque pretreated testing site in comparison to placebo control pretreated testing site, for the five days. There was no significant difference in comparison on each day among the Proteque, vehicle, and SLS only test sites.

2) Transepidermal water loss (TEWL) on Proteque pretreated testing site was significantly decreased in comparison to SLS only treated site, and also in comparison to placebo control pretreated testing site on day 2, 4 and 5.


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