Preventing irritant contact dermatitis:
an in vivo human study
Study Director: Howard Maibach, M.D.
Principal Investigator: Hongbo Zhai, M.D.
Technical Assistance: Alessandra Pelosi, M.D.
Hongbo Zhai, M.D.
Department of Dermatology
University of California
San Francisco, CA 94143
This study was to evaluate the efficacy of a Proteque formulation against sodium lauryl sulfate
(SLS) induced irritation by visual grading and bioengineering techniques in humans.
1) Visual scoring (VS) of erythema showed a decrease on the Proteque pretreated testing site in comparison to SLS only treated site; and it also
significantly decreased the VS on Proteque pretreated testing site in comparison to placebo control pretreated testing site, for the five days. There
was no significant difference in comparison on each day among the Proteque, vehicle, and SLS only test sites.
2) Transepidermal water loss (TEWL) on Proteque pretreated testing site was significantly decreased in comparison to SLS only treated site, and
also in comparison to placebo control pretreated testing site on day 2, 4 and 5.