||North Carolina State University
Reduction of irritation by a non-corticosteroid topical agent
Nancy Ann Monteiro-Riviere, Ph.D., Dipl. ABFM
Professor of Investigative Dermatology
Center for Cutaneous Toxicology and Residue
North Carolina State University
Raleigh, North Carolina
- Assess efficacy of Proteque Skin Protection System to modulate sodium lauryl sulfate (SLS) induced contact dermatitis.
- Proteque Skin Protection System is a non-corticosteroid lotion consisting of dimethicone, triclosan (Irgasan DP300), tocopheryl acetate,
Aloe Vera Gel, and Lonicera Japonica in a proprietary base formulation.
- White weanling Yorkshire pigs (n="4" replicates per treatment).
- SLS (1% and 3%) applied to 4.0 cm² Hill Top Chambers provided a suitable degree of irritation assessed by a Draize erythema score
(scale 0-4) at 24 and 48 hours.
- Effects of pre-treatment (15 minutes) and post-treatment with Proteque lotion was investigated to determine its effects on SLS-induced
- Effects of cleansing skin before Proteque lotion application was assessed.
- Role of triclosan was investigated using Proteque lotion with/without this additive.
- Effects of application of Proteque on reducing UVB-induced photo-irritation was also assessed in a separate study.
- SLS reproducibly induced a Draize level 2-3 erythema.
- Application of Proteque lotion significantly blocked erythema, especially when applied after SLS dosing.
- These results were consistent whether 1 or 3% SLS was applied.
- Use of cleanser before Proteque lotion had no effect.
- Proteque lotion without triclosan was equally effective at reducing SLS-induced irritation.
- UVB alone produced a Draize level 3 erythema, which pre-treatment with Proteque lotion reduced to a level 1.
- Proteque lotion reduced UVB-induced sunburn cell formation from 50 to 3, and reduced histological index of skin damage significantly.
- Application of Proteque lotion significantly reduced SLS-induced irritation when applied after SLS treatment. Triclosan was not the active
ingredient modulating this effect.
- Similarly, treatment with Proteque lotion prior to UVB exposure markedly reduced the severity of sunburn achieved.
- These data confirm the efficacy of Proteque lotion to reduce SLS- and UVB-induced skin irritation.